This study examines the prevalence of unmet medical needs and their impact on health-related quality of life in the general population. Using the EQ-5D-5L questionnaire and a survey based on previous Greek research, data from 712 participants revealed that 47% of respondents had unmet health needs, mainly due to cost and long waiting times. Although they generally reported good health, many respondents, especially women, had significant mental health problems that affected their quality of life. The results show that lower levels of education, chronic diseases and older age are strongly associated with poorer health outcomes and greater unmet needs. The study emphasises the need to improve healthcare services, particularly by strengthening the role of GPs to ensure better treatment and monitoring of chronic conditions. Addressing these inequalities is critical to improving overall public health and ensuring equitable access to health services.